About Gerty Cori
Gerty Theresa Cori (née Radnitz; August 15, 1896 – October 26, 1957) was a Czech and American biochemist who in 1947 was the third woman to win a Nobel Prize in science, and the first woman to be awarded the Nobel Prize in Physiology or Medicine, for her role in the "discovery of the course of the catalytic conversion of glycogen". Cori was born in Prague, the capital of Bohemia within the Austro-Hungarian Empire. Growing up at a time when women were marginalized and allowed few educational opportunities, she gained admittance to medical school, where she met her future husband Carl Ferdinand Cori in an anatomy class. Upon their graduation in 1920, they married. Because of deteriorating conditions in Europe, the couple emigrated to the United States in 1922. Gerty Cori continued her early interest in medical research, collaborating in the laboratory with Carl. She published research coauthored with her husband, as well as publishing singly. Unlike her husband, she had difficulty securing research positions, and the ones she obtained provided meager pay. Her husband insisted on continuing their collaboration, though he was discouraged from doing so by the institutions that employed him. Together with her husband Carl and Argentine physiologist Bernardo Houssay, Gerty Cori received the Nobel Prize in 1947 for the discovery of the mechanism by which glycogen—a polysaccharide made from glucose—is broken down in muscle tissue into lactic acid and then resynthesized in the body and stored as a source of energy (known as the Cori cycle). They also identified the important catalyzing compound, the Cori ester. The Coris were the third ever married couple to win the Nobel Prize. In 2004, both Gerty and Carl Cori were designated a National Historic Chemical Landmark in recognition of their work in clarifying carbohydrate metabolism. In 1957, Gerty Cori died after a ten-year struggle with myelosclerosis. She remained active in the research laboratory until the end of her life. She received recognition for her achievements through multiple awards and honors. In 1929, they proposed the theoretical cycle that later won them the Nobel Prize, the Cori cycle. While working at Washington University, they discovered an intermediate compound in frog muscles that enabled the breakdown of glycogen, called glucose 1-phosphate, later known as the Cori ester. Months before she won the Nobel Prize, she was promoted to full professor, a post she held until her death in 1957.
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