About Nicholas A. Peppas
Nicholas (Nikolaos) A. Peppas is a chemical and biomedical engineer whose leadership in biomaterials science and engineering, drug delivery, bionanotechnology, pharmaceutical sciences, chemical and polymer engineering has provided seminal foundations based on the physics and mathematical theories of nanoscale, macromolecular processes and drug/protein transport and has led to numerous biomedical products or devices. Peppas was the first to develop novel toxic-free poly(vinyl alcohol) gels by the freezing-thawing technique in 1975. Using intelligent polymers as early as 1980, Peppas and his group were the first to use such pH-sensitive and temperature-sensitive systems for modulated release of streptokinase and other fibrinolytic enzymes. He was the first to set the theories and equations that led to the design of a wide range of new systems. In 1979 his group pioneered the use of hydrogels in drug delivery applications, including epidermal bioadhesive systems and systems for the release of theophylline, proxyphylline, diltiazem, and oxprenolol.
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